The Prefecture of Larisa is in Thessaly and borders with Pieria and Kozani to the north, Grevena, Trikala and Karditsa to the west, Fthiotida and Magnisia to the south and the Aegean Sea in the east with approximately 270,600 inhabitants.

The town of Larisa, the capital of the Prefecture, is spreadout on the infinite plain crossed by the River Pinios. A modern, cosmopolitan town with interesting sights, the Acropolis, ancient theatres, the monument and Museum of Hippocrates, Alcazar Park, the traditional houses at Tabakika and the fortress, the archaeological museum, the gallery and the Cultural Historical Museum are definitely worth seeing.

The hamlet Agia built on the slopes of the Ossa mountain, the resort Agiokambos with a sandy beach and the historical village Ambelakia built on the Straits of Tembi.